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Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

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Controlled six-month study of oral folic acid therapy in boys with fragile X-linked mental retardation. Am J Med Genet ; The effect of nutritional supplementation on calorie and protein intake of pregnant women. Nutr Rep Intl ; Oral magnesium supplementation and the prevention of preterm labor. Am J Obstet Gynecol ; Nutritional profile of newborns of adolescent mothers supplemented with iron, in different concentrations, zinc and pholic acid.

Brazilian Journal of Nutrition ; Effect of the Bvitamins on cognitive function in elderly people with mild cognitive dysfunction.

Clin Chem Lab Med ; Mortality and cardiovascular events in patients treated with homocysteine-liowering B vitamins after coronary angiography. Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer ; Blinded comparison of folic acid and placebo in patients with ischemic heart disease: Preventing the recurrence of neural tube defects in South Carolina. Proc Greenwood Genet Center ; Vitamin supplementation and neural tube defects.

Daly L and Graham I. Interactions between homocysteinaemia and conventional risk factors in vascular disease. Eur Heart J ;15 suppl: The effects of oral vitamin supplementation on cardiovascular risk factors.

Roc Nutr Soc ; Effects of single and combined B-vitamin supplementation on homocysteine concentrations in different population groups. University of Bonn, Bonn, Germany.

Plasma homocysteine response to folate intervention in young women. B-vitamin supplementation lowers homocysteine levels in heart disease. Vitamin requirements for the reduction of homocysteine blood levels in healthy young women [dissertation]. Maternal folate status during extended lactation and the effect of supplemental folic acid. Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease.

Randomized trial of the effect of supplementation on the cognitive function of older people with subnormal cobalamin levels. The responsiveness of plasma homocysteine to small increases in dietary folic acid: Disorders of homocysteine metabolism: Proceedings of an international symposium.

Fulda, Germany, November Folic acid and Vitamin B6 supplementation and plasma homocysteine concentrations in healthy young women. Prevention of preeclampsia by linoleic acid and calcium supplementation: Reduction of plasma homocyst e ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease.

Vitamins and progression of atherosclerosis in hyper-homocyst e inaemia. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid.

The natural history of vascular disease in homocystinuria and the effects of treatment. Ponz de, Leon M. Chemoprevention of colorectal tumors: Scand J Gastroenterol Suppl ; Essential fatty acids preparation SR-3 improves Alzheimer's patients quality of life. Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men. Folic acid fortification of the food supply. Potential benefits and risks for the elderly population.

Zinc supplementation during pregnancy: The Hordaland Homocysteine Study. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Blood folic acid and vitamin B12 in relation to neural tube defects. Br J Obstet Gynaecol ; Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. Its occurrence, cofactor therapy, and enzymology. Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: Low-dose aspirin and incidence of colorectal tumors in a randomized trial.

J Natl Cancer Inst. Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis.

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Br J Surg ; Hyperhomocysteinemia and the response to vitamin supplementation. Treatment of mild hyperhomocysteinemia in vascular disease patients. A prospective study of plasma homocyst e ine and risk of ischemic stroke. Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocysteinaemia in vascular patients.

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Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction. Relation of serum homocysteine and lipoprotein a concentrations to atherosclerotic disease in a prospective Finnish population based study. Folate supplementation and adenomatous colonic polyps.

Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia. Premature infants require additional folate and vitamin B to reduce the severity of the anemia of prematurity. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Vitamin requirements for the treatment of hyperhomocysteinemia in humans.

Prevention of anemia in premature infants? Effect of sulindac on sporadic colonic polyps. Periconceptional vitamin use, dietary folate, and the occurrence of neural tube defects. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Folic acid absorption in women with a history of pregnancy with neural tube defect.

Apparent prevention of neural tube defects by periconceptional vitamin supplementation.

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Influence of routine administration of folic acid and iron during pregnancy. Maternal folate status, birthweight and gestational age. Anemia of pregnancy in Liberia, West Africa: Effects of extended systemic and topical folate supplementation on gingivitis of pregnancy.

The influence of folic acid on the frequency of epileptic attacks. Eur J Clin Pharmacol. Studies on the effect of folic acid supplement on folate and vitamin B12 status in children. Southeast Asian J Trop. Med Public Health ; A randomized controlled trial of prenatal nutritional supplementation in New York City.

Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Can vitamins prevent neural tube defects? Med Assoc J ; Folic acid therapy in the fragile X syndrome. Am J Med Genet. A prophylactic supplementation of iron and folate in pregnancy. Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease. Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland.

Plasma and red cell folate values and folate requirements in formula-fed premature infants. Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Possible prevention of neural-tube defects by periconceptional vitamin supplementation.

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Folacin requirement of children. The prevention of megaloblastic anaemia in pregnancy in Nigeria. Influence of folic acid on birthweight and growth of the erythroblastotic infant. Effect of folic acid supplementation. The effect of folic acid and iron in the prevention of nutritional anaemias in pregnancy in Nigeria.

Br J Nutr ; Reduction of incidence of prematurity by folic acid supplementation in pregnancy. Prophylaxis of anemia in pregnancy. Relationship of vitamin B12 and folic acid to memory function. Folic acid supplement and intrauterine growth. Though only about a third of the bill has been revealed, our imagination is running wild with dreams of euphoric singalongs in the hot Costa Rican sun. For tickets and more information click here.

Swing Original Monks will showcase their essential mix of electronic beats and traditional rhythms while acts like La Madre Tirana and Quixosis highlight the boundary pushing sounds of the Ecuadorian underground.

Now in its fifth year, the festival attracts locals and visitors from across Central America, with a massive lineup catering to rock, hip-hop, reggae and EDM fans. Organizers have also invited several international artists, like Colombian psych lunatics Meridian Brothers and Chilean pop princess Javiera Mena, while also curating a small discovery stage for showcasing local garage bands.

Entering its second year as a major attraction in Guanajuato, about two hours outside Mexico City, organizers are doubling down on their commitment to the national indie scene with a stellar sophomore lineup. Influential indie rock acts Porter and Hello Seahorse! The festival plays out as a series of intimate but packed concerts, workshops, and comedy shows across Mexico City, with talent ranging from buzzy to legendary. Festival Marvin takes place May 17—19 in Mexico City. Find tickets and more information here.